KESUM - Comparative Analysis. Reduces Amyloid Plagues (RCT-backed), 2% increase BDNF enhancement support neurogenesis.

 

Clinical Comparison Table highlighting KESUM’s unique neuroprotective & metabolic benefits compared to other well-researched herbs/supplements: 

KESUM

Perfect BDNF 

KESUM

Brain De-Rived Nuerotrophic Factor BDNF.

KESUM

 

Neuroprotective & Cognitive Health Supplements: Comparative Analysis

NEUROPROTECTIVE & COGNITIVE HEALTH SUPPLEMENT : COMPARATIVE ANALYSIS.

CRITERIA	KESUM (polygonum Minus)	Bacopa monnieri	Lion’s Mane (Hericium erinaceus)	Gingko Biloba	Curcumin (turmeric)
BDNF Enhancement	✅ Provent in RCTs (2% Increase) support neurogenesis & synaptic	🟡 Mild increase (animal studies) human data inconsistent.	✅ Stimulate NGF / BDNF (mostly preclinical )	❌ No direct BDNF boost, improves bloodflow.	🟡 Indirect BDNF modulation (via anti-inflammatory effects).
Beta – Amyloid Prevention	✅ Reduces amyloid plaques (RCT – backed)	❌ No direct evidence.	✅ May reduce amyloid ( animal studies )	🟡 Mild anti-amyloid (antioxidant effects)	✅ Strong anti-amyloid (but poor bioavailability)
Uric Acid Reduction	✅ Lowers uric acid by 18% week (animal / human data).	❌ No known effect	❌ No know effect	❌ No know effect	🟡 Mild reduction (linked to anti-inflammatory effets).
Cognitive Benefits	✅ Memory, focus verbal recall ( testimonials + RCTs )	✅ Improves memory (slow onset 6-12 weeks)	✅ Mood cognition ( limited human trials)	✅ Executive function (vascular support)	🟡 Mixed results (absorption issues)
Sleep / Headache Relief	✅ Reported in testimonials (non-sedative mechanism).	❌ No direct effect	❌ No direct effect	❌ May cause headaches in some	🟡 Indirect (via inflammation reduction).
Gold-Standard RCTs	✅ Human trials BDNF / amyloid	✅ Memory studies (but not BDNF-specific	❌ Limited human RCTs.	✅ Extension vascular / cognition trials.	✅ Anti-inflammation trials (few on cognition)
Key Mechanism	✅ BDNF + anti-amyloid + uric acid reduction (multi-target).	Acetylcholine modulation	Nerve Growth Factor (NGF) stimulation	Vasodilation /antioxidant	Anti-inflammation / antioxidant
Bioavailbility	✅ Natural, no reported absorption issues.	🟡 Requires fat for absorption	🟡 Dependent on extraction method	🟡 May interact with blood thinner	❌ Poor absorption without enhancers (e.g.piperine)

 

KESUM

KESUM

KESUM

1. KESUM is Unique for its triple action: 

   -  BDNF boost (RCT-proven). 

   - Amyloid prevention (direct dementia protection). 

   - Uric acid reduction (metabolic + neuro benefits). 

 

2. Outperforms Competitors in: 

   - Speed of cognitive effects (testimonials suggest rapid benefits vs. Bacopa’s slow onset). 

   - Whole-brain health (most herbs target 1–2 pathways; KESUM covers 3+). 

 

3. Safety Edge: No major interactions reported (unlike Ginkgo’s bleeding risk or curcumin’s absorption challenges). 

 

Clinical Implications 

- For Dementia Prevention: KESUM’s anti-amyloid + BDNF combo is superior to single-mechanism herbs. 

- For Metabolic Brain Health: Uric acid reduction adds vascular/cognitive protection (similar to allopurinol’s neuro effects). 

- For Daily Nootropic Use: Testimonials support tolerability and multi-domain benefits (sleep, focus, pain relief).